Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This volume explores the nature of ellipsis, the core phenomenon that results in various types of omission in sentences.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Natural product inspired antibiotics to address resistance

Supervisor: Gerard van Westen

Promotor: Prof.dr. M. Ubbink

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: G.P. van Wezel

Kohei Suzuki is Assistant Professor at Institute of Public Administration. This study carries several important implications for understanding the policy impacts of a graying population and for studies of the welfare state, in general.

Scientific integrity is an essential element in the PhD trajectory and is addressed in several different settings.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Congratulations, you have completed all the steps for admission and application, so you are a Leiden University student now! Below you can find a few tips to start at Leiden University well prepared.

You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.

The Dutch Center for Travel Writing Studies s a scientific center that develops and coordinates initiatives to promote research into travel writing. It actively seeks contact with external (scientific and social) partners to collaborate on issues surrounding cultural / national identity, cultural contact…

Behrouz Karoubi defended his thesis on 15 June 2016

Objects and framings of heritage, archives, and academic knowledge production generate worldwide, fierce societal debates on the legacies of colonial violence, past injustice and present-day institutional racism. Whether bronzes from Benin, daggers from Bali, fossils from Java, photo-albums from…

The ASCL Research Programme for the years 2019-2024 is called ‘Strident Africa: Societal and Environmental Change in the Context of 50 Centuries of History’. It examines the dramatic changes taking place on the continent in terms of population growth, urbanization, the role of external actors and the…

An integrated geo-archaeological research of the hominin site Trinil on Java

A research team from Leiden University, in cooperation with Bureau Boekhoorn Sociaal-Wetenschappelijk Onderzoek en Advies (BBSO), is to evaluate Dutch counterterrorism legislation.

What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?

This research cluster centres on regional, national, and global intersections between a variety of artistic and cultural expressions and their role in society from 1800 onwards.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

The Hague is a real student city and has everything you’ll need to turn your time as a student into the time of your life.

Does knowledge of environmental performance change farmer's behaviour?

Leiden students can go to LAC institutions with which Leiden University has signed student exchange agreements.

This Research Master’s programme will train you to become a researcher.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

How is structural and functional brain development related to behavioral change in cognitive-control, impulse regulation, and socio-emotional functioning?

The Institute of Education and Child Studies aims to create a challenging academic environment in which students can flourish.

The tree-year bachelor's programme in Archaeology is a many-sided programme in which you study societies, cultures, and human behaviour from the past, aiming to reconstruct and revive them. Dive into the development of human societies all over the world, from the Americas to the Middle East, from the…

What is the impact of research-based learning on critical thinking competence and academic achievement in undergraduate education? What are underlying factors of research-based learning in the learning environment?

Edegar da Conceição Savio defended his thesis on 28 January 2016

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.