Promotor: Prof.dr. T. Schmidt

As of 1 September, Marco van Eijk has been appointed Director of Education of the bachelor's programme Life Science & Technology. He succeeds Marcellus Ubbink, who moved to the position of Scientific Director of the Leiden Institute for Chemical Research (LIC). Van Eijk has been appointed for a period…

Danica Mast, PhD candidate at LIACS, investigates how technology can encourage people to move more. In Mare she explains more about the so-called exertion interfaces and her research at Lowlands.

A CT scanner to treat eye cancer, energy-efficient software for the future and a test to identify male chick eggs. Three projects by researchers from Leiden University are to receive funding from research funder NWO’s Open Technology programme, to which the business sector also contributes.

Technological innovations such as home dialysis could significantly improve the quality of life and health of kidney patients. Professor Joris Rotmans therefore wants to continue pushing for new medical technology, as he will explain in his inaugural lecture on 24 March.

On 6 and 7 May 2021, KBR, in partnership with the Campus Condorcet of Paris, the National Library of Luxembourg, the KB national library of the Netherlands, the universities of Ghent, Leuven, Liège, Mons and Namur, and the Vlaamse Erfgoedbibliotheken, will be holding an international conference on medieval…

It is often thought that immigration threatens the solidarity on which redistribution relies. But looking at the post-war period, PhD candidate Emily Anne Wolff finds that this is not the case.

More than 60 European researchers and industry partners have set out their roadmap for the application of graphene in marketed products. Leiden chemist Grégory F. Schneider believes that graphene and other layered materials can in the future be used for DNA sequencing applications.

On 10 May Maarten Aalbers, PhD-fellow and research staff member at the Europa Institute, participated in the “State Aid Compliance Seminar”, hosted by Europa decentraal, the EU law center for local and regional authorities in the Netherlands. Maarten Aalbers presented on the interaction between EU competition…

What can continuity and change in the manufacturing of locally made ceramics from the early colonials Spanish towns of Concepción de la Vega, Cotuí and Nueva Cádiz (1492-1600) tell us about the choices people made in ceramic production as a reaction the the changing social environment?

Bioenergy with carbon capture and storage (BECCS) is a promising method for removing carbon dioxide (CO2) from the atmosphere and simultaneously generating energy. Yet this method is controversial, as it may require a great deal of land and water. Researchers at Leiden University have now proposed a…

CADS lecturer Sander Hölsgens is one of the initiators of the NWO Smart Culture Project Documenting Complexity (project number CISC.KC.212). This project investigates how and why engaged documentary filmmakers use new technologies in their work. One of the outputs of this project is the series ‘In Whose…

The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.

What legislative and regulatory questions arise when children, adolescents or elderly people use the Internet?

As part of the state visit to Mexico a theme lunch on indigenous cultures was organised.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

An overview of the research at the Cancer Dug Target Discovery group.

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

In this paper, the authors outline how the UK and USA adopt the Chilean pension model without proper attribution, potentially distorting the lessons.

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

What is the role of auxin in the initiation and process of somatic embryogenesis?

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

The law and Artificial Intelligence (AI) applications need to be better aligned to ensure our personal data and privacy are protected. PhD candidate Andreas Häuselmann can see opportunities with AI, but dangers if this does not happen.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

How did changes in the composition and exploitation of princely domains in various principalities of the Low Countries influence the development of ‘modern’ public finance systems, including the notion of public debt?

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw- Center for Law and Digital Technologies, just published a book on Robots, Healthcare, and the Law. Regulating Automation in Personal Care.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Scientists of the faculty of Governance and Global Affairs research completely different subject, among which terrorism, cybercrime and migration. In the upcoming weeks we will give the floor to several of our very best researchers. In this episode: migration researcher Alexandre Afonso.