Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

Last week, the results of the 2016 call for proposals of the European Institute of Technology Raw Materials (EIT RM) became available. Both Leiden University and Delft Unversity of Technology are partners in this Knowledge and Innovation Community, in which some 100 research institutes, industries and…

Technological developments never stop. Machines can already perform many tasks and in the future they will probably take over even more of the work we do. Which jobs could disappear and which will remain in the future? Olaf van Vliet, Professor of Economics at Leiden Law School, commented on these issues…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Promotores: J. Jonkers, K.E. de Visser

Vaccination via the skin or the mucosae

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Anjali Pandit, René Olsthoorn and Alia Matysik.

The imaging group focuses on bio-imaging, image analysis and visualization.

The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

How do plant defense genes get activated?

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Supervisor: Maarten Doornbos

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

On 7 February, the first co-creation event of the Expanding (Event) Horizons project took place at Leiden University. Nearly 30 educators, scientists and consultants from diverse backgrounds designed inclusive projects for engaging students from underrepresented minority groups with educational Science…

Public funding for fundamental research is essential for innovation and the development of new medicines. This is demonstrated by Professor Science Based Business Simcha Jong and his colleague Hsini Huang after studying US federal funding restrictions for stem cell research under President George W.…

Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…

Can we reshape school playgrounds through data and design? By using AI and wearable sensors, data scientist Maedeh Nasri discovered ways to create environments where children, including those with ADHD and autism, can connect, play, and grow.

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.