Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

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The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Key publications of the Aging and Immunity group

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Er is een nijpend cellen- en personeelstekort in Nederlandse gevangenissen. En dit is niet voor de eerste keer. Miranda Boone, hoogleraar criminologie en vergelijkende penologie, sprak met Trouw over de problematiek: ‘Het aantal gevangenen is het resultaat van beleid.’

Science, Leiden Academic Centre for Drug Research (LACDR)

Salt crystals, a nano-sized golf stick and molten glass. The LION Image Award competition of 2023 yielded a lot of beautiful images once again. But in the end, only one can be the winner.

PhD defence

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

Songbirds apparently use mnemonics rather than more complex grammatical rules to recognise structures in which they have been trained. Leiden behavioural biologist Caroline van Heijningen published an article on this subject on Tuesday 17 November in PNAS.

An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.

PhD defence

On 27 May 2021 (15.15-18.00), the Utrecht Centre for Medieval Studies will host its annual colloquium via Zoom. This colloquium will consist of a general lecture by Mauro Bonazzi and paper presentations by Bart van Hees, Nike Stam, and Irene O'Daly.

The Ig Nobel prize is awarded annually to ten studies that first

The adventure of iGEM Leiden has come to an end. The result: prizes for Best Therapeutic Project and Best Model, a gold medal, a successful crowdfunding campaign and of course their open-source research findings, which are available for the scientific community.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

Last Thursday, the April edition of the ILS Lunch Seminars took place. This well attended seminar featured criminal- and criminological issues from an Interaction between Legal Systems’ perspective, with presentations from Adriano Martufi and Marco Stam.

The new book of Professor of Character evolution and biodiversity Menno Schilthuizen gained a lot of media attention. ‘Darwin comes to town – how the urban jungles drives evolution’ was published in English in February and will be available in Dutch soon.

Professor Fons Verbeek of the computer science and biology institutes at Leiden University has the fascination to visualize everything we can not see immediately. At SleutelstadFM he tells us that by converting 2 dimensional (2D) images to 3 dimensional (3D) structures, research is carried out into…

PhD defence

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

Supervisor: Anna Vlachodimou