2,105 search results for “war on drug” in the Public website
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Career prospects
With an MSc degree in BPS and Science Communication & Society you are well prepared for a broad array of career prospects in research or industry. The master’s degree is an excellent preparation for a career at the interface of science and public affairs.
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Knowledge from now
Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.
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Armenians Beyond Diaspora: Making Lebanon their Own
This book argues that Armenians around the world – in the face of the Genocide, and despite the absence of an independent nation-state after World War I – developed dynamic socio-political, cultural, ideological and ecclesiastical centres. And it focuses on one such centre, Beirut, in the postcolonial…
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Historian Gert Oostindie the new Cleveringa Professor
Gert Oostindie, Emeritus Professor of Colonial and Postcolonial History, is this year’s Cleveringa Professor at Leiden University. He was appointed by the University on 4 October. In his inaugural lecture on 24 November, entitled Courage and Disregard, he will talk about (academic) freedom in relation…
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Negotiating Peace with Your Enemy: The Problem of Costly Concessions
Why do some parties fail to settle conflict, even after long periods of fighting? ISGA PhD candidate Valerie Sticher suggests that costly concessions often stand in the way of a negotiated agreement. Conflict party members not only care about their in-group's welfare, but also want to avoid rewarding…
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Teaching
At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Systems pharmacology of the endocannabinoid system
What are the functions of the endocannabinoid system?
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Master's application and admission
Find out how to apply for Drug Discovery and Safety at Leiden University by following our step-by-step guide.
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Key publications
Key publications of the Computational Drug Discovery group
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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Contact
Do you have questions about the Bio-Pharmaceutical Sciences master’s programme or the specialisation Drug Discovery and Safety? Please contact us.
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Leiden University during the Second World War
Event
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Postdoc - Translational Pharmacology in antibiotic regimen development
Science, Leiden Academic Centre for Drug Research (LACDR)
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Leiden University and LUMC join Netherlands Centre for One Health
Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.
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Taking a closer look at resistance to tuberculosis bacteria
Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…
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Horizon Europe grant for research into personalised treatment for high blood pressure
Professor Thomas Hankemeier and his international research team HYPERMARKER have received a 10m-euro grant from Horizon Europe and UK Research and Innovation.
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The conduct of hostilities under international humanitarian law - challenges of 21st century warfare
The central question is whether the current regime of international humanitarian law governing the conduct of hostilities in armed conflict is still adequate to deal with modern conflict scenarios, or whether it needs revision or amendment.
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Help for students
Are you a student from Ukraine, Russia, or any other country and do you have questions about the war? Or are you looking for help or advice? Find out who you can turn to and what you can do to help yourself and others.
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Polish Holocaust researchers accused of defamation will give Cleveringa Lecture
On 26 November historian Jan Grabowski and sociologist Barbara Engelking will both give the Cleveringa Lecture. They wrote a book about the Holocaust in Poland and were taken to court for defamation.
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Cleveringa Professor Frank van Vree: ‘It’s high time to discuss the ritualisation of the past’
The annual commemoration of the nation’s war dead on Dam Square and at Waalsdorpervlakte, the Dutch apologies for historical slavery and the Cleveringa Lecture itself: our relationship with history is often ritualistic, Cleveringa Professor Frank van Vree will say in his inaugural lecture on 27 Nove…
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A History of the National Security State in Turkey
Zeynep Sarlak defended her thesis on 25 August 2020
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South Africa, Race and the Making of International Relations
This book offers readers an alternative history of the origins of the discipline of International Relations.
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Freedom and the Fifth Commandment. Catholic priests and political violence in Ireland, 1919-21
A new paperback edition of Brian Heffernan's book Freedom and the Fifth Commandment. Catholic priests and political violence in Ireland, 1919-21 was published by Manchester University Press in September 2016.
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International Politics (MSc)
This master’s programme focuses on understanding the causes and consequences of armed conflict between states and within states. In addition, we explore whether and how local, national and international actors and institutions can forge cooperation, prevent political and armed conflict from emerging,…
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EUniWell welcomes Taras Shevchenko National University of Kyiv
Taras Shevchenko National University of Kyiv (KNU), a leading Ukrainian university, is now a member of the EUniWell Alliance. KNU and the EUniWell partners will use their combined strengths to improve the well-being of individuals, communities and societies in Europe and beyond, through international…
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Science
There are eight institutes at the Faculty of Mathematics and Natural Sciences:
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Light relief
How can new compounds relieve cancer patients of severe side effects?