De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Supervisor: Gerard van Westen

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Source: ChemMedChem (2015)

Supervisor: Gerard van Westen

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

During the course of drug discovery translational steps are made.

Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

Leiden University is ending the experiment with the Binding Study Advice in the second year of the bachelor's programme (BSA 2) with immediate effect. Under the terms of BSA 2, students were required to obtain 90 credits within two years, including their first-year diploma.

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

‘Huis van het Boek/Museum Meermanno in The Hague exhibits book bindings by leading Dutch Art-Nouveau artists from the period 1890-1910. The exhibition will be open from March 22 to June 23 2019. The title of the exhibition is De Bijzondere Band: Art Nouveau-boeken van Dijsselhof, Lion Cachet en Nieu…

Op deze pagina vind je antwoorden op veelgestelde vragen.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

On this page you will find all information about the Bachelor of Security Studies that you need as a first-year student.

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

During the early modern period, many medieval manuscripts were cut up into strips of parchment which were reused to reinforce the bindings of newly printed books. Until recently, these reused pieces of medieval manuscripts only came to light when the early modern book binding was damaged and/or subjected…

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Promotor: M. Ubbink, Co-promotor: G. Siegal

Supervisor: Maarten Doornbos

Supervisor: Lizi Xia