1,409 search results for “biomarker discovery” in the Public website
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Exhibition celebrates a century of astronomical discoveries
Some of the most significant and surprising astronomical breakthroughs that have shaped science, technology and culture over the last century are showcased in the Above and Beyond open-source exhibition. This exhibition was commissioned within the framework of the International Astronomical Union's…
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Astonishing explorations at the Night of Discoveries
It was the Night of Discoveries on Saturday 16 September: a summer encounter between art and science. Leiden researchers from various disciplines inspired the public with their quest to understand our world.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Mario van der Stelt
Science
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Gerard van Westen
Science
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Madeline Kavanagh
Science
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Fundamental and translational medical biochemistry
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Four bold Faculty of Science researchers receive NWO XS grants
Four scientists from the Faculty of Science will receive a grant of up to 50,000 euros in the Open Competition Domain Science - XS from science financier NWO. This category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea.…
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Leiden discovery of planetary births is worldwide news
In Germany, the United States and even in Vietnam: all over the world, the Leiden discovery of the birth of two planets was shared. Astronomer Sebastiaan Haffert and his team were able to record multiple planets in the making for the first time and published their findings in Nature Astronomy. A unique…
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Nobel Prize for physics: 'Clear solutions are the best discoveries'
What does Leiden physicist Wolfgang Löffler think about the award of the Nobel Prize for physics to Arthur Ashkin, Gérard Mourou and Donna Strickland?
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Discovery of a new Philippine monitor lizard (Varanus bitatawa)
'A spectacular new Philippine monitor lizard reveals a hidden biogeographic boundary and a novel flagship species for conservation' . CML-researcher Merlijn van Weerd has participated in a new article in Biology Letters about this discovery.
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European collaboration shines a light on enzyme discovery for industry
A European consortium has provided a disruptive technological breakthrough to allow the discovery and characterization of novel enzymes for industrial biotechnology. The technology will open the way to more efficient industrial processes such as in the biofuel, animal feed and paper and pulp industr…
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Rethinking drug discovery: Vidi grant for Laura Heitman
Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Coen van Hasselt
Science
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Three discoveries for cleaner and cheaper fuel
How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.
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Het belang van de biomarker
Inaugural lecture
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Leiden discovery leads to new ageing cream and chicken feed
What do a novel anti-ageing ingredient for cosmetics and a new type of chicken feed have in common? They were both produced using a new solvent developed by Leiden biologists in 2011. The medium is neither solid nor liquid, and the industry is now starting to see it’s many possibilities.
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Leiden discovery evaluated by world-leading breeding companies
Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.
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Presentations eLaw at 'Brave New World' and 'Night of Discoveries'
eLaw - Center for Law and Digital Technologies, is well represented at a number of activities in Leiden this week concerning Technology and Society!
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De Witte et al publish in Nature Drug Discovery Reviews
Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange
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New discoveries by the Leiden-Turin excavations in Saqqara
Archaeologists from the National Museum of Antiquities (Leiden), the Museo Egizio (Turin, Italy) and Leiden University have found the grave of Panehsy, the 'steward of the temple of (the god) Amun', in Saqqara.
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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The archaeological discovery at the Paardenmarkt in Alkmaar
In the summer of 2010, a special archaeological find resurfaced when plans to redevelop the Paardenmarkt, a parking lot in the historic city center of Alkmaar, began.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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First discovery of high-energy neutrino source
For the first time, scientists have traced back a high-energy neutrino to its source in space. It was produced by a so-called blazar—a supermassive black hole. Researchers from neutrino detector IceCube report this in Science. ‘This is a milestone for neutrino science,’ says physicist Dorothea Samtleben…
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Freek Vonk gets his own show on Discovery Channel
Biologist Freek Vonk had already appeared in the Time Warp programme, where he was shown milking a snake for its venom, which he needed for his doctoral research. On Friday 18 September, he explained his fascination for snakes to Matthijs van Nieuwkerk in ‘De wereld draait door’, a Dutch news and entertainment…
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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Better treatment of skin diseases thanks to NWA grant of 11.7 million euros
Patients with skin diseases such as eczema and psoriasis, sometimes spend a lifetime searching for the right medication. To help these patients faster and better, scientists across the country are joining forces. The Next Generation ImmunoDermatology (NGID) project, with LACDR professor Robert Rissmann…
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ACTION
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Alumnus Robert Ietswaart: ‘Machine learning is revolutionising drug discovery’
Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…
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Neurodevelopmental risks in young children with an extra X or Y chromosome
This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.
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Remarkable PhD research: diagnosing sepsis in premature babies
How can we diagnose the life-threatening condition sepsis in premature babies as quickly and accurately as possible? That is what PhD student Manchu Thangavelu from the Leiden Academic Centre for Drug Research (LACDR) wants to figure out.
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Will this discovery help us develop better catalysts?
Where exactly on the surface of a catalyst do the chemical reactions occur? Until now, it has always been a challenge to identify the exact locations of these ‘active sites’. In a new article in Nature, Leiden chemists helped their international colleagues reveal new insights into this issue. Their…
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PhD Research || Re-discovery of the Italian salterio
It was her original Salterio from 1725, built by Michele Barbi, which Franziska Fleischanderl could coincidentally acquire in 2014 that ignited her passion for this special string instrument. Before, she was focussed on contemporary music with modern Hackbrett.
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Astronomer Joe Callingham testifies against killer stars in new show on Discovery Channel
On Friday evening 17 September, Leiden astronomer Joe Callingham can be seen in a new series on Discovery channel. Killers of the Cosmos is about different deadly dangers lurking in the depths of space. Asteroids, cosmic debris, electromagnetic weapons… The show takes a film-noir approach to these threats,…
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Leiden archaeologists mentioned in Top 13 Discoveries in Human Evolution during 2023
In a recent article published on PLOS, Drs. Briana Pobiner and Ryan McRae of the Smithsonian Institution National Museum of Natural History discuss the top 13 discoveries in human evolution in 2023.
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Artificial intelligence as the co-pilot for drug discovery
There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…
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Key publications
Key publications of the Predictive Pharmacology group.
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Anthe Janssen
Science
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Discovery of a unique silver bowl from the Early Middle Ages
On an excavation site in Oegstgeest Leiden University archaeologists discovered a very rare silver bowl from the first half of the seventh century. The bowl is decorated with gold-plated representations of animals and plants and inlaid with semi-precious stones. The discovery suggests the existence…
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Rob van Wijk discusses the role of zebrafish in drug discovery
Rob van Wijk gave an interview on the role of zebrafish in drug discovery and development, published in FIGON’s journal Medicines as a preview of LACDR’s representation at the PhD competition during the Dutch Medicines Days (DMD). The entire interview can be read below.
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Night of Discoveries: 3D-printed paintings and the effects of psychedelics
Come to the Night of Discoveries art and science festival on 16 September. Various researchers from the university are speaking at the festival.
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Strategy
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Flurry of new discoveries as incredible new image revealing 4.4 million galaxies is made public
Over a seven year period an international team of scientists has mapped more than a quarter of the northern sky using the Low Frequency Array (LOFAR), a pan-European radio telescope. From Leiden, Astronomer Timothy Shimwell and Huub Röttgering, among others, are involved. It reveals an astonishingly…