927 search results for “genetics he modification” in the Public website
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Biomolecular analyses of skeletal remains in the circum-Caribbean across the historical divide (A.D. 1000-1800)
As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Animal welfare
We carry a profound responsibility for our research animals and strive to provide them with the best possible quality of life. In our studies, we make every effort to avoid and minimise discomfort for the animals. Below, you can learn more about how this is put into practice.
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Key publications
Key research articles and book chapters of the Chromatin group.
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Unravelling the genes responsible for life history traits in the giant woody cabbage (Brassica oleracea)
Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?
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Awards and Grants 2017
An overview of awards and prizes granted to our staff and students in 2017, as well as special appointments and royal distinctions.
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Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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Lend me your ears: the grammar of (un)transferable possession
The main aim of this project is to investigate the various ways in which language categorizes possession, how these are morphosyntactically encoded across and within languages, and how this distinction should be represented in a model of the language faculty.
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Evolution & Biodiversity in Plant Sciences
Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.
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South American population history revisited: multidisciplinary perspectives on the Upper Amazon
This project, South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE), investigates population dynamics in western South America on the basis of traces in the geographical, genetic, archaeological, ethnological, and linguistic record.
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Open Data: The Researcher Perspective
Combining results from bibliometric analyses, a global sample of researcher opinions and case-study interviews, a new report reveals that although the benefits of open research data are well known, in practice, confusion remains within the researcher community around when and how to share research…
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The Silk Road Language Web
A linguistic prehistory of the Tarim Basin in Northwest China
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Bioactive Molecules in Plant Sciences
Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.
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On the representation of quantity: how our brains shape language
This project investigates properties of quantity expressions across languages from the perspective of how quantity is represented in the human brain.
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igraph - To modernize the igraph interfaces to make network analysis easier
igraph development focused on improving the most-used interfaces, which are Python, R, and Mathematica. Additionally, the developers aim to make the library and the interfaces easier to maintain, focusing on long-term sustainability. This ensures that igraph continues to be a useful tool for network…
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SKY HIGH: Vertical farming a revolution in plant production
As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Heterogeneity in spores of food spoilage fungi
This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.
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Cattle-talk: the language of colour among East African pastoralists
What categories exist in the languages of pastoralists? Do these semantic concepts reflect universal or languagespecific tendencies? What (environment? culture?) governs the similarities (or the differences) attested crosslinguistically in cattle colour systems?
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Required documents
When you apply for admission, you’ll be asked to submit several documents.
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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MtDNA Barcoding Invasive Species
What is the provenance of introduced populations?
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Yearly expansions
Every year YAL welcomes new members to its community. Below you will find an overview of the expansion of the past few years.
- Application deadlines
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Information activities
Get to know us through our online and in-person events for prospective students!
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Vidi grants for nine Leiden researchers
From artificial intelligence to letters from the Dutch East Indies and from breast-cancer gene BRCA-1 to the collaboration between government and opposition: nine researchers from Leiden University have been awarded a Vidi grant for their research.
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ESOF ‘Art Exploring Science’ session will connect art and science
How can we view societal challenges from a different perspective? At the EuroScience Open Forum (ESOF), Robert Zwijnenberg, Emeritus Professor of Art and Science Interactions, will call for more collaboration between artists and scientists.
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Jaap van den Herik wins Humies Award 2014
The paper Genetic Algoriths for Evolving Computer Chess Programs by Omid E. David, Jaap van den Herik, Moshe Koppel, Nathan S. Netanyahu has won the Humies Award 2014 (human-competitive results produced by genetic and evolutionary computation).
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Effects of glufosinate-ammonium on off crop vegetation
Description of Effects of glufosinate-ammonium on off crop vegetation.
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Admission requirements
To be eligible for Molecular Genetics and Biotechnology at Leiden University, you must meet the following admission requirements.
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Biology student wins Young Talent graduation prize for Plant Sciences
Recently graduated Biology student Julia López Delgado is one of the winners of the Holland Society Young Talent Awards 2019. She received her prize during the festive award ceremony on 25 November in Haarlem.
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eLaw Alumnus wins European Data Protection Law Review ‘Young Scholar Award’ at CPDP
Taner Kuru, an eLaw alumnus, was awarded the prestigious European Data Protection Law Review ‘Young Scholar Award’ for his paper on the shortcomings in the GDPR for the regulation of genetic testing at the prestigious Computers, Privacy and Data Protection Conference (CPDP).
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Wrestling with SUMO proteins
The work done by SUMO proteins in the cells of our body is of vital importance. Molecular cell biologist Alfred Vertegaal has been studying these proteins for nine years, first with a Veni subsidy and then with a prestigious Vidi subsidy.
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Medical Delta Professor Eline Slagboom: ‘The delta region is where everything comes together’
Professor Eline Slagboom has been studying multiple generations of families for over 20 years. She collects data on why some people age healthily and others decline early.
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Vici grants for four Leiden researchers
Four Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Academic Research (NWO).
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LCCP Working seminar spring 2022
The seminar is dedicated to the work-in-progress of Leiden Centre for Continental Philosophy staff and doctoral students. The paper is sent in advance and discussed in the meeting. The seminar is open to all. Venue: Lecture room or zoom.
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Biogeochemical Biographies
A multiple isotope approach to human-animal dynamics in the Lesser Antilles across the historical divide
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Learning from the past
Leiden archaeologists investigate how people in the past impacted their environment. Together with scientists, environmental scientists, and humanities experts, they use this information to draw conclusions about the present – and show what we can learn from it for the future.
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Techniques en philosophie
Many stimulating philosophical analyses have been written on contemporary technology; this book examines on the contrary how changes in contemporary technological environment have been reflected onto philosophy itself. The book shows how technological changes have marked a number of key concepts of…
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Attentional processing of itch and pain
This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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Solid State NMR and modelling of photoinduced energy and electron transfer
Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
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Fine Mechanical Department
What is the Fine Mechanical Department?
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Mapping Sex-by-genotype Interactions in Brain Functions
Fatemeh (Simin) Tabassi Mofrad has recently received a project grant (€ 25,000) from LUF/Gratama Foundation for her ideas in investigating sex-by-genotype interactions in brain functions. She has a multidisciplinary research perspective which enables her to look at research issues from different angles.…
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.