1,704 search results for “drug development” in the Public website
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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A much-needed new class of antibiotics
Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…
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Kiki Zanolie
Faculteit der Sociale Wetenschappen
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Anna van Duijvenvoorde
Faculteit der Sociale Wetenschappen
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Arnout Koornneef
Faculteit der Sociale Wetenschappen
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Tailored medicines
Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.
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Media use and brain development during adolescence
Nowadays children grow up with social media. This may influence the development of brain regions involved in social interaction. In their review article in Nature Communications, Crone and Konijn illustrate how neuroscience can contribute to a better understanding of how media and peers influence adolescents'…
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Research projects
An overview of research projects at the Predictive Pharmacology group.
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Postdoc Pharmacometrics for anti-infective pharmacology and pandemic preparedness
Science, Leiden Academic Centre for Drug Research (LACDR)
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Skin researcher calls for multidisciplinary collaboration: ‘I want to pool expertise’
In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…
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Peer feedback in teacher professional development
This dissertation set out to provide both an integrated framework for the practices of teacher peer feedback and an in-depth understanding of teacher peer feedback in the Chinese vocational education context.
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Mario van der Stelt
Science
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Roxanne Kieltyka
Science
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Gerard van Westen
Science
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Madeline Kavanagh
Science
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Andrea Spruijt
Faculteit der Sociale Wetenschappen
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David Zetland
Faculty Governance and Global Affairs
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Zijian Li
Faculteit der Sociale Wetenschappen
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Inge van der Weijden
Faculteit der Sociale Wetenschappen
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Kiki Spaninks
Science
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Evelien Urbanus
Faculteit der Sociale Wetenschappen
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Christine Mummery
Faculteit Geneeskunde
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Sheila van Berkel
Faculteit der Sociale Wetenschappen
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Anar Ahmadov
Faculty Governance and Global Affairs
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Barbara Gravendeel
Science
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Jimena Pacheco Miranda
Faculteit der Sociale Wetenschappen
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Shannon Yuen
Faculteit der Sociale Wetenschappen
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George Miley
Science
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Marja Oudega
Faculteit der Sociale Wetenschappen
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Jennifer Anderson
Science
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Liza van den Bosch
Faculteit der Sociale Wetenschappen
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Ili Ma
Faculteit der Sociale Wetenschappen
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Nienke Wieringa
ICLON
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Maria Gabriela Palacio Ludeña
Faculty of Humanities
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Marieke Bos
Faculteit der Sociale Wetenschappen
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Tales Yamamoto
Science
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Leiden Institute of Chemistry
The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.
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comprehensive understanding of (facilitating) teacher professional development
What are ‘missing links’ in research on teacher professional development trajectories? We focus on the role and development of teacher facilitators in designing and implementing (collaborative) professional development trajectories.
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Foreign capital and colonial development in Indonesia
The proposed research program studies the impact of private foreign investment on development in Indonesia during the years c. 1910-1960.
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Novel receptor concepts
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Smartmix: A new generation of efficient biomedical research
Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?