934 search results for “genetics he modification” in the Public website
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The Syntax of Object Marking in Sambaa: A comparative Bantu perspective
This thesis investigates the syntax of object marking in Sambaa and the Bantu languages in general, with particular focus on Swahili and Haya, as points of comparison.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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XXY versus autism: evidence from neuroimaging
Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI
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The Leiden Family Lab study on Social Anxiety Disorder
Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.
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Safeguarding genome integrity with small ubiquitin-like modifers
PhD defence
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The linguistic past of Mesoamerica and the Andes: a search for early migratory relations between North and South America
The aim of the project is to unravel the genetic and contact relations between the indigenous languages of Mesoamerica (Mexico and western Central America) and the Middle Andes region (Ecuador, Peru, Bolivia), as part of a larger endeavor to understand the historical process of the peopling of the Americas…
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Development of organ-on-a-chip systems for translational and personalized medicine
We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.
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Evolution & Biodiversity
Evolution & Biodiversity is one of the four research themes of the Institute of Biology Leiden.
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Leiden iGEM students win two prizes in international biology competition
The students of iGEM Leiden 2021 have scored well in the eponymous biology competition: they won a Gold Medal and the Best Safety & Security Award. The student team received the awards for their project DOPL LOCK, in which the team tries to make genetic modification safer.
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Reedijk Symposium 2024: Understanding and exploiting epi-glycome active enzymes
Lecture
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Rob Schilperoort Memorial unveiled at Leiden Bio Science Park
The Rob Schilperoort Memorial will be unveiled at the Leiden Bio Science Park on Saturday 16 September. This gigantic gate stands at the entrance to the park, which is also named after Schilperoort, its founder.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Social Anxiety and Specific Phobia in Youth
From basic science to real-world interventions
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
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'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.
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Degradome analysis of vaccines
The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.
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The amorphous 6-string
This research intents to redefine the limits of the electric guitar.
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VOILA (Validation of Innovative Lipopeptide Antibiotics)
Examining the therapeutic potential of new semisynthetic lipopeptide antibiotics
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Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Personalized Medicine
Getting personal
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The prehistoric origin and spread of the Indo-Iranian languages
A linguistic test of hypotheses rooted in genetics and archaeology.
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Development & Disease in Microbial Sciences
Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.
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Master's application and admission
Find out how to apply for Molecular Genetics and Biotechnology at Leiden University by following our step-by-step guide.
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Indigenous cultural heritage and intellectual property
Challenges for the protection of traditional knowledge and genetic resources, traditional cultural expressions, and traditional knowledge of indigenous peoples in the international scenario.
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Dormancy in stochastic interacting systems
Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Contact
Do you have questions about the master’s specialisation Molecular Genetics and Biotechnology? Please contact us.
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Cryptic species discovery
Do understudied animals contain hidden species?
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FAQ research with animals
Antwoord op veelgestelde vragen over onderzoek met proefdieren bij de Universiteit Leiden. FAQ
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Leiden discovery evaluated by world-leading breeding companies
Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.
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Auxin
Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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About the programme
The specialisation consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Paul Hooykaas
Science
- Lectures
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Theoretical Linguistics
Studying the underlying principles of the nature of language.
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Inverse problems for universal deformation rings of group representations
Promotor: P. Stevenhagen, Co-promotores: B. de Smit, F. Andreatta
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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A micro-trial study to investigate the effectiveness of public speaking treatments in children
Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Mass Torts in Europe
In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.
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The role of the interleukin 12 family in atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager