384 search results for “smit barrie repair” in the Public website
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RE-PAIR: Unravelling the Impact of Emotional Maltreatment on the Developing Brain
What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?
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Bart de Smit appointed as professor Algebra and Number Theory
On Tuesday 15 September 2015, Bart de Smit has been appointed as professor of Algebra and Number Theory at the Mathematical Institute of Leiden University.
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Laurens Smit awarded for best PhD student in Operations Research/Management Science
The New Jersey Chapter of the international Institute for Operations Research and the Management Sciences
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age
On 27 June 2019, Barry Bussey defended his thesis 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. The doctoral research was supervised by Prof. dr. P.B. Cliteur.
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Meindert Lamers
Science
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Anna Babl
Faculteit der Sociale Wetenschappen
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Sylvia de Pater
Science
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International Law and Cybersecurity Governance
This edited publication aims at reflecting on the future of discussions on the applicability of international law to States’ use of ICTs in the context of highly politicised discussions at the multilateral level and offering practical suggestions for the European Union to pursue its objectives in this…
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Torsion points on elliptic curves over number fields of small degree
Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent
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Break-through in the genetic modification of plants
A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…
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Vascular and Regenerative medicine
With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.
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Development of formulation for treatment of Atopic Eczema
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High fidelity DNA replication and repair
PhD defence
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Enhancing epicardial EMT to repair the heart
PhD defence
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Efficient gene-targeting during meiosis
Efficient gene-targeting during meiosis
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Participate
Wanted for the Re-pair study!
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Worm and stomach bacteria: our allies in the battle against allergic asthma
Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.
- Meet our staff
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Key publications
Key publications of the Aging and Immunity group
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Exposure and health Assessment of Persistent Organic Pollutants (POPs) at e-waste recycling site among workers in the informal sector in Nigeria
Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Teachers and students as partners in researching educational practice
How can collaborative participatory action research by student-teachers and their students enhance student participation, improve educational practices, and generate knowledge about these practices that can be used for improving teacher education as well?
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Education
Education and Organisation Development
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Organisation
The staff members of the Methodology & Statistics unit are members of various boards and committees.
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Roman-Catholic reactions to Protestant 'moderns' in the Netherlands, 1840-1870
Ineke Smit defended her thesis on 17 September 2019
- Meet our staff
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Control of replication associated DNA damage responses by Mismatch Repair
PhD defence
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
PhD defence
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
PhD defence
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
- Publication highlights
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Mersenne primes and class field theory
Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Culture: text and images in Japan
One of the ways of understanding another culture better is to examine what people experience when they read a text, or look at an image. Leiden experts have a lot of knowledge in this field, for example on culture in ancient Japan.
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Decolonising International Justice
Around the world, there is a growing movement to decolonise university curricula, with both students and educators seeking to disrupt existing epistemic hierarchies within higher education. This research project aims to unravel what decolonising means in general and what it means for the International…
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Weak coupling between magnetically inequivalent spins: the deceptively simple, complicated spectrum of a 13C-labeled trimethyl amine
A deceptively simple, complicated paper
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Youth and safety
Policy studies and interventions in the field of Youth
- Meet our staff
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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People
Overview of the Leiden Asia staff per area or country.
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Millions of people to help with new synthetic skin cream
A team of researchers has managed to recreate the most natural skin cream in existence. Using the DUBBLE beamline (Dutch Belgian Beamline) at the European Synchrotron Radiation produced on the basis of the information identified, has the same properties as vernix caseosa. This cream may have a therapeutic…
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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