The mission of science based business (SBB) connects the domains of science, business, and policy. Scientific research we focus on at Leiden in areas such as artificial intelligence promises to reshape our societies for the better. Translating science into positive societal impact however requires new…

Business Studies spans science, medicine, and business, focusing on areas such as technology management, innovation, entrepreneurship, operations, and decision making.

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

On 11 October, Amanda Pasma defended the thesis 'Re-entry support from prison-based and community-based professionals'. The doctoral research was supervised by Paul Nieuwbeerta, Hanneke Palmen and Esther van Ginneken.

How do museum visitors interpret the authenticity of museum objects? How can we support visitors' meaningful interactions with real objects?

Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.

Promotor: K.J. Batenburg

The Agent Based Modelling for Archaeologists (ABMA) project is dedicated to developing Open Educational Resources (OERs) and accompanying materials for agent-based modelling (ABM) in Archaeology.

Towards a framework that integrates content-based and process-based accounts of mathematical thinking

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Promotor: Prof.dr. H.A.G. Wijshoff

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

How can teachers be motivated by their students’ data in making stepwise changes to their teaching practices?

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Markus Davidsen defended his thesis on 16 October 2014

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

What are the key issues in conducting LCA of bioenergy systems? What is the environmental sustainability status of second generation bioethanol? How much would the final results of biogenic carbon neutrality assumptions deviate from the true values based on a complete inventory? How to assess the impact…

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotores: Wim Jiskoot; Ferry Ossendorp

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Access to information is a human right (United Nations, 1948). Information technology, such as search engines and recommender systems, has become the key mediator and facilitator to connect people to information (White, 2016). Conversational artificial intelligence (AI) technology is increasingly being…

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

This research proposal focuses on the investigation of the poetic potentials of negativity through the exploitation of failure in sound based artistic practices - a context that has not been extensively addressed.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Corporate R&D organizations and their relation to academic laboratories.

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

This study helped to identify and summarize how value-based healthcare (VBHC) is conceptualized in the literature and implemented in hospitals. Furthermore, an overview was created of the effects of both the implementation of VBHC and the implementation strategies used.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

What is the effectiveness of two school-based skills-training programs in promoting mental health?

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.