The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…

The Center for Interdisciplinary Placebo Studies Leiden (IPS) aims to advance the understanding of placebo and nocebo effects, their underlying mechanisms, and their potential applications in clinical practice. IPS consists of a group of interdisciplinary researchers working at Leiden University with…

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

Positive expectations can influence sensations of itch and evoke placebo effects, whereas negative expectations can trigger nocebo effects in itch. There is evidence that placebo effects can occur even when people know that they are taking a placebo. Little is known about how these so-called open-label…

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

While many healthcare professionals indicate that they frequently use placebo effects and their mechanisms, there is little formal training on how to deal with placebo and nocebo effects in clinical practice. This project aims to address this gap between scientific knowledge on placebo and nocebo effects…

If a pill containing no active ingredients still helps, this positive expectation is called a placebo effect. A negative expectation is called a nocebo effect. Both can be produced by verbal suggestions and conditioning. According to Andrea Evers’ research group, combining these is the most promising…

Medicines can work even if they have no active ingredient. The first international scientific conference on placebos will take place in Leiden from 2 to 4 April. Placebo researcher Andrea Evers, who is also chairing the conference, answers some pressing questions.

Even if you have a healthy lifestyle, there's a lot to experience and learn during the Healthy University Week, from 26 to 30 October. Health psychologist Andrea Evers is enthusiastic about the week ahead. She tells us about the programme and gives us a taste of her own talk on what the placebo effect…

We aim to create an innovative e-learning and virtual reality training that helps healthcare providers to optimize placebo effects and minimizes nocebo effects via their communication.

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

From painful joints to intense fatigue: a third of rheumatism patients suffer serious effects from this chronic condition and rely long-term on medication. Leiden psychologists are to receive a subsidy from the Netherlands Arthritis Foundation to investigate whether placebo techniques can help patients…

Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

Two Leiden researchers of the Institute of Psychology have been given the opportunity to realise their research plans for the coming three years thanks to a Veni grant from the Netherlands organisation for scientific research. Hanneke Hendriks is researcher in the field of Social and organisational…

The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…

The research connected to this topic is related to Work and health.

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

Is it possible to pharmacologically condition oxytocin responses in healthy individuals and identify the neural circuitry underlying such conditioning?

In his book The magic of healing, Willem van der Does talks about 14 pioneers in the history of psychiatry. These pioneers all had one thing in common: they started with a radical idea which led to great enthusiasm.

Stimulating the vagus nerve, which provides a direct link between the gut and brain, makes people pay less attention to sad facial expressions. This research study by psychologists Katerina Johnson and Laura Steenbergen is published in the journal Neuroscience, and made it to the cover.

The research connected to this topic is related to E-health.

Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato

To relieve a patient's pain, it can be effective to induce expectations. This finding is promising for optimising the effectiveness of treatments, conclude Kaya Peerdeman and colleagues in their article in PAIN.

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

If a new method has been developed to recognize and treat a (neuro-)psychological disorder or related behavioral factors, it cannot yet be used directly in clinical practice. First, the method should be evaluated, preferably in randomized controlled trials.

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

Andrea Evers is the new Professor of the brand-new unit of Health, Medical and Neuropsychology. She's getting off to a flying start in Leiden with a consolidator grant of the European Research Council (ERC). Her ambition? 'To work together with other disciplines; that way we can arrive at new insigh…

Leiden University will be recording a brand-new series of podcasts in 2019: Science Shots. Our top scientists will talk about their research in less than 15 minutes. Tip: something to enjoy on the train journey between Leiden and The Hague, our two University cities!

Overview of the CML reports

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

Music can affect how we feel, think, and behave. But how do we learn about the specifics of people's responses to music so that we can apply this to health and well-being? By looking at characteristics of the music, as well as the differences between listeners, we hope to better understand as well as…

Does an Emotional Working Memory Training show a beneficial transfer effect on emotion regulation (reappraisal) capacities in patients with Borderline Personality Disorder?

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.