1,190 search results for “anti-cancer drug steen” in the Public website
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Templates
To achieve a more consistent and professional look in our scientific posters. A new template has been chosen. This design and its principal elements can be downloaded here.
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In vitro and in vivo evaluation of synergistic and opposing effects of Chinese herbal medicine and natural compounds on immuno-modulation.
Can we link multiple components from herbal extracts with their biological activities?
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Historic Chinese Materia Medica revisited
What are the differences between the trade in Chinese herbal drugs in Europe between 1800 and now? Can we see the major metabolic changes after 200 yours?
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Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.
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MeRGeR: Physiological significance of the glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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Endocannabinoids in health and stress
How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Teris van Beek
Dr. at the Department of organic chemistry, Wageningen University - the Nederlands
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Fiji
FIJI is one of the most used image analysis tools in the world. FIJI stands for FIJI is just ImageJ, it is however much more.
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Rechtsgeleerdheid (specialisation) (LL.B.)
In de afstudeerrichting Rechtsgeleerdheid aan de Universiteit Leiden leer je alles over nationaal, Europees en internationaal recht. De opleiding is breed, maatschappelijk relevant en heel concreet. Tijdens colleges worden actuele onderwerpen besproken, gekoppeld aan de wetenschappelijke theorie: kinderrechten,…
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Law (LL.B.)
Consumer complaints, the war against drugs, family issues, matters of state: Rechtsgeleerdheid (Law) is socially relevant and topical.
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Research groups
The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.
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Hall of Fame 2020
In 2020, many of our staff and students have again won prestigious prizes and been awarded important research subsidies.
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Brand-new professor Gerard van Westen wants to cross boundaries
Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…
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Improving painkiller dosing in the clinic
Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…
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Six million boost to search for new antibiotics
Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.
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Security and threat
Polarisation in our society is on the rise. What makes people increasingly radical? How do we protect ourselves from extremist, terrorist or criminal threats, be they physical or in the cyber world? And what role do intelligence services play in this?
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Europe 1000-1800 (MA)
In the master's programme Europe 1000-1800 at Leiden University you will learn to think comparatively about practices of power in premodern Europe in its global context.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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Homicide
A research into homicide.
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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Research
Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Programme
Everyone is welcome at the Leiden Science Family Day. We have set up a programme with a variety of activities for children, teenagers and adults.
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Schedule
The Gorlaeus Building will be constructed in three phases, with the new building due to be completed by 2028.
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Unveiling the invisible conformational landscape of cytochrome P450
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Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation
Source: PLoS ONE, Volume 10, Issue 3 (2015)
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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A document classifier for medicinal chemistry publications trained on the ChEMBL corpus
Source: J Cheminform, Volume 6, Issue 1 (2014)
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Master Bio-Pharmaceutical Sciences
This page provides information to support your application for the Master's programme of Bio-Pharmaceutical Sciences.
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
Source: J Cheminform, Volume 7, Issue 1 (2015)
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Monitoring the penetration process of single microneedles with varying tip diameters
Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.