2,409 search results for “mathematical and statistical modelling” in the Public website
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Education
Methodology & Statistics offers bachelor's courses and a master's specialisation.
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Knowledge extraction in the quantum random-oracle model
The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.
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In search of the atoms of mathematics
Combining geometry and number theory. That is what Dr Jan Vonk of the Institute of Mathematics receives a Vidi grant for today. ‘By fusing these two disciplines we may be able to solve a century-old mathematical problem.’
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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‘Ūd Taqsīm as a Model of Pre-Composition
In this research project Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).
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A recipe for desert: analysis of an extended Klausmeier model
Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk
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Minipigs as an Animal Model for Dermal Vaccine Delivery
Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.
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Marc Spijker
Science
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Onno van Gaans
Science
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Hermen Jan Hupkes
Science
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Marcel de Jeu
Science
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Arjen Doelman
Science
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Frank den Hollander
Science
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe
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Contact
Contact details secretariat section Methodology & Statistics.
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Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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Why the mathematics of operations research is so fascinating – even for a layperson
Floske Spieksma will give her inaugural lecture as Professor of Mathematics of Operations Research on 1 September. A discussion about mathematical models, Venezuela, trembling knees, being the only woman, casinos, intuition and above all loving your job.
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Invasive plant species, models for evolutionary change
Which traits did change due to the invasion process of plants and how do these traits contribute to the invasiveness of such species. What is the role of carbohydrate accumulation? What is the function of carbohydrate accumulation in plants? Is genetic variation depleted in invasive species under se…
- About this minor
- Data Science & Artificial Intelligence
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Bergson and the Aristotelian model of immanent teleology
This dissertation addresses the different use of the same philosophical model: immanent teleology. In this work Aristotle, the founder of the study of final causes, is put in relation with the modern French evolutionary thinker Henri Bergson, the philosopher of time. The dissertation tackles the two…
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Mathematical Institute cooperates with UWV
Marta Fiocco, associate professor at the Mathematical Institute of Leiden University, has signed an agreement with the UWV (the administrative authority that implements employee insurances and provides labour market and data services) to work with their data in the research project
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Deconstructing stability. Modelling changing environmental conditions and man-land relations in the Pleistocene landscape of Twente (2850 - 12
The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.
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New section makes statistics understandable
‘Statistics? I hated that hard subject in school’, statistician Sanne Willems is often told. And that is a pity, she thinks, because statistics doesn’t necessarily have to be difficult. Together with two former fellow students, she set up a Statistics Communication section for good communication on…
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Contact
The programme group Research Methods and Statistics is part of the Institute of Education and Child Studies. This group is located in the Faculty of Social and Behavioural Sciences of Leiden University near Central Station.
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Lattice models for Josephson junctions and graphene superlattices
In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.
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Paul Nieuwbeerta affiliated professor at Statistics Netherlands
From April 2022, Professor Paul Nieuwbeerta will be working one day a week as affiliated professor for Statistics Netherlands (Centraal Bureau voor de Statistiek (CBS)). He is Professor of Criminology at the Institute of Criminal Law and Criminology, Leiden University.
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Elsevier: Mathematics in Leiden best education according to researchers
Research from weekly magazine Elsevier shows that both the Leiden bachelor Wiskunde as the master Mathematics are rated as the best educational programs of the Netherlands according to professors. The first place was achieved by up to 70% of the votes.
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Statistics for the benefit of the patient
Marta Fiocco has been appointed as of 1 April as professor of applied mathematics, in particular medical statistics. Fiocco's appointment is at the Faculty of Science and at the Leiden University Medical Centre (LUMC). She conducts research into 'personalised medicine', tailor-made medicines for cancer…
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Child Cancer Fund subsidises statistical research
Marta Fiocco, professor in the Mathematical Institute, has received a grant for analysing data on chemotherapy in children suffering from leukaemia. The work involves developing and applying new statistical methods that will help determining the optimal dose of chemotherapy.
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Big data cannot do without statistics
Data science and statistics are closely linked, says Spinoza laureate and Stochastics professor Aad van der Vaart. We talk with him about the big data hype, genome research and collaboration with other disciplines. ‘Statistics helps wherever data is not perfect.’
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The Chilean Model of Pension Reform as a Lopsided Exportschlager
In this paper, the authors outline how the UK and USA adopt the Chilean pension model without proper attribution, potentially distorting the lessons.
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Reconstruction and Computational Modelling for Inherited Metabolic Diseases
Accelerating the diagnosis and personalising the management of inherited metabolic diseases.
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Harold Nefs
Faculteit der Sociale Wetenschappen
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Sarah Plukaard
Faculteit der Sociale Wetenschappen
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Frans Rodenburg
Science
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Statistical modelling of time-varying covariates for survival data
PhD defence
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Indefinite integration through recognition based heuristic search
Towards a framework that integrates content-based and process-based accounts of mathematical thinking
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Martina Chirilus-Bruckner
Science
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Martha Dellar
Science
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.