How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotores: J. Jonkers, K.E. de Visser

Eine Archäobotanische untersuchung zu Umwelt und Landwirtschaft der Ältesten Bankkeramik.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

I. Die Ausgrabungen am Weinberg 1965 bis 1970. Mit Beiträgen von A.T. Clason, M.E.Th. de Grooth, L.H. Keeley und K.J.H. Vriezen.

This dissertation provides a detailed description of the interaction between verb semantics and the two grammatical voice categories in the Vedic Sanskrit of the Rigveda.

Analecta Praehistorica Leidensia is the annual journal of the Faculty of Archaeology (formerly the Institute of Prehistory), Leiden University.

How do mycobacteria subvert the defenses of host immune cells?

This doctoral thesis focuses on Paisiello's partimenti and how to approach their realization and performance.

This dissertation deals with Hegel’s theory of the sublime (das Erhabene). I focus specifically on die heilige Poesie (sacred poetry), a form of art that he identifies with the Judaic Psalms and which I claim to be the core of Hegel’s approach to sublimity. I claim that Hegel’s apparent lack of interest…

How did a circle of Soviet artists and writers virtually unknown until perestroika turn into Russia’s most influential contemporary art movement? This book reconstructs the cultural history and canonization of a group of painters and poets known as the Moscow conceptualists, who paradoxically did not…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

My research addresses the function of the much-debated particle -nā in Biblical Hebrew, often translated with “please”, from the point of view of the most important ancient Bible translations (Greek, Syriac, Latin). It combines textual criticism, translation technique, discourse pragmatics, and the…

The recent rise in global migration movements and the simultaneous attempts to prevent migrations to the Global North in general and Europe in particular have produced numerous images and narratives that try to record and convey these events and their actors.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

How can zebrafish research help to understand and fight human cancer?

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

A full overview of MCBIM PhD theses.

Former masterstudent Bio-Pharmaceutical Sciences Maddalena Centanni will be awarded the 2020 Arenberg Coimbra Prize for Erasmus Students. Centanni spent her six month Erasmus exchange at Uppsala Universiy in Sweden where she looked for ways to improve anti-cancer drug dosing.

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

30 October 2021 – 4 December 2021 SPACE, Liège (BE)

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

How can new compounds relieve cancer patients of severe side effects?

Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

PhD defence

PhD defence

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…

PhD defence

Lecture

Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

China wordt steeds assertiever in zijn relaties met andere landen, maar achter dit beeld gaat een opmerkelijk diverse maatschappij en politieke realiteit schuil die tal van aanknopingspunten biedt voor samenwerking en verdere integratie van China in de wereld. In China een gids voor de 21e eeuw past…

PhD defence

De menselijke geschiedenis strekt zich ver uit vóór de tijd waarin de mensen opschreven wat er zoal gebeurde.

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

How do macrophages and neutrophils contribute to metastatic onset?

Conference

In welke mate hebben domaniale structuren de machtsvorming en nederzettingsontwikkeling in en van het gewest Holland bepaald?

Hoe kan de City Deal Kennis Maken bijdragen aan het formuleren van maatschappelijk relevant onderzoek dat de stad in al haar diversiteit centraal stelt? In de stad Leiden zijn burgers momenteel maar in beperkte mate betrokken bij het bepalen van de agenda van de lokale City Deal Kennis Maken. Dit onderzoeksproject…