62 search results for “immunotherapy” in the Public website
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Immunotherapy to limit atherosclerosis-projects
For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.
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Classical conditioning to improve immunotherapy in cancer
Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Liposomes as delivery system for allergen-specific immunotherapy
In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.
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Exploring liposome-targeted chemotherapy combined with immunotherapy in cancer
PhD defence
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Specialised immune cells have potential for new cancer immunotherapies
Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…
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NKI-AVL and LUMC are joining forces in immunotherapy
Strengthening a cancer patient's own immune system so that the body itself can better destroy cancer cells. This is at the heart of immunotherapy, the most promising progress in cancer treatment in recent years. In order to drive this development further, the Netherlands Cancer Institute-Antoni van…
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Cationic liposomes loaded with a synthetic long Peptide and poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell
For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…
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Poly-(lactic-co-glycolic-acid)-based particulate vaccines: particle uptake by dendritic cells is a key parameter for immune activation
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…
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Therapeutic Immunomodulation
The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.
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Immunotherapy in advanced melanoma - crossing borders
PhD defence
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Immune system plays dual role in breast cancer
The immune system plays a paradoxical role in the spread of breast cancer. Some immune cells contribute to metastasis, while other cells can be activated to strengthen the effect of chemotherapy. Kelly Kersten made this discovery in her PhD research. PhD defence 7 February.
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Improving immunotherapy for melanoma: models, biomarkers and regulatory T cells
PhD defence
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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immunostimulatory properties of oncolytic reovirus for anticancer immunotherapy
PhD defence
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Optimizing immunotherapy in locoregional and metastatic urothelial cancer
PhD defence
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.
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Get to know Transfusion Medicine and Cellular and Tissue Therapies
The 100% online master programme Transfusion Medicine and Cellular and Tissue Therapies will equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. Its current concept includes both transfusion of blood components and hematopoietic transplants, cellular…
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Get to know Transfusion Medicine and Cellular and Tissue Therapies
The 100% online master programme Transfusion Medicine and Cellular and Tissue Therapies will equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. Its current concept includes both transfusion of blood components and hematopoietic transplants, cellular…
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The T cell-myeloid axis in the success and failure of cancer immunotherapy
PhD defence
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Everyone works better together:Rational improvements to radio- and immunotherapy combinations
PhD defence
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Biomarkers for the response to immunotherapy in patients with non- small cell lung cancer
PhD defence
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
PhD defence
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint two-year parttime Master's programme will equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. Its current concept includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy and immunotherapy.…
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Center for Interdisciplinary Placebo Studies Leiden
The Center for Interdisciplinary Placebo Studies Leiden (IPS) aims to advance the understanding of placebo and nocebo effects, their underlying mechanisms, and their potential applications in clinical practice. IPS consists of a group of interdisciplinary researchers working at Leiden University with…
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Faculty of Science
Explore the unknown in order to be able to innovate in the distant future.
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Programme structure
Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.
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Cancer cells play hide-and-seek with immune system
When the immune system attacks cancer, the tumour modifies itself to escape the immune reaction. Researchers at LUMC published on this subject in Nature on 28 June.
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Five ERC Starting Grants for young researchers from Leiden
The ERC has awarded a Starting Grant to five promising researchers from Leiden. Two are from the Faculty of Social and Behavioural Sciences, one is from the Faculty of Humanities/Governance and Global Affairs, one from the LUMC and one from the Faculty of Science.
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Spinoza and Stevin prizes for LUMC professors
Sjaak Neefjes, professor of Chemical Immunology at the LUMC, has been awarded a Spinoza prize of 2.5 million euros. His colleague Ton Schumacher, professor of Immunotechnology affiliated with Leiden University, the LUMC and the Antoni van Leeuwenhoek cancer centre, has been awarded the Stevin prize,…
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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Important developments in lung cancer surgery
Professor of Cardiothoracic Surgery, in particular pulmonary surgery, Jerry Braun will give his inaugural lecture on Friday 23 September entitled ‘Out of countless millions’. Braun has been a professor and acting head of the LUMC’s Department of Cardiothoracic Surgery since January 2020. Covid meant…
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How do we maintain a healthy biological clock?
During Seeing Stars Leiden all the lights around Leiden Observatory will be switched off for an hour. The more lights that go out, the more stars we’ll be able to see. For the LUMC, this is the perfect moment to think about our biological clock, the topic researchers from the BioClock consortium are…
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Company Visit Ocello
On the 21st of September, seven students of SBB visited OcellO at the Biopartner 2.
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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Vidi grants for 12 researchers from Leiden University
An impressive 12 researchers from Leiden University have been awarded an 800,000-euro grant by the Dutch Research Council (NWO). This will enable them to develop their own line of research over the next five years.
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Leiden Bio Science Park: connecting with the community
For Harry Flore, chair of the LBSP business asociation and CEO at Hal Allergy, the Leiden Bio Science Park (LBSP) has no secrets. But he can well imagine the park is a black box for some staff and students at the university: 'I welcome collaboration on all fronts.'
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.