934 search results for “genetics he modification” in the Public website
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Arabidopsis AGC3 kinases and PIN plasma membrane abundance
The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
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Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU
On 3 September 2019, Ilektra Antonaki defended her thesis 'Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU'. The doctoral research was supervised by Prof. S.C.G. Van den Bogaert.
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Integrating palaeoproteomics into the zooarchaeological analysis of Palaeolithic bone assemblages
Doctoral Thesis
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About
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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Neandertal Legacy
The genetic material of currently living Europeans is partly of Neandertal origin. Were our ancestors successful because they were hybridising and interacting with the local populations they encountered when migrating into new places? Reconstructing our evolutionary trajectory is key for rethinking…
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Bayesian uncertainty quantication in complex models
The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.
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Searching for the concrete subject: On the epistemic role of lived-experience in Paul Natorp's critical epistemology
The following dissertation reconstructs Paul Natorp's philosophical psychology. It argues that psychology's main object is the lived experience of concrete subjects, understood as a transcendental structure of logical-reflexive conditions for the recognition, appropriation, and evaluation of objective…
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Robert Zwijnenberg: what makes us human?
Advanced biotechnology allows us to select or alter the genetic makeup of human embryos. What limits do we impose on biotechnological intervention in nature and the human body? And whose call is that?
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Duality for Interacting Particle Systems
Duality, stochastic processes
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Cancer Pathogenesis and Therapy
Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.
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IAFPA research grant for Willemijn Heeren and Lei He
Willemijn Heeren has, together with dr. Lei He (Department of Linguistics, Tübingen & Center for Forensic Phonetics and Acoustics, Zürich), received a research grant from the International Association for Forensic Phonetics and Acoustics to start a pilot project on “Between-speaker variability in dynamic…
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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Standardized and reproducible measurement of decision-making in mice
In science, it is of vital importance that multiple studies corroborate the same result. Researchers therefore need to know all the details of previous experiments in order to implement the procedures as exactly as possible. However, this is becoming a major problem in neuroscience, as animal studies…
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Profiling Endophenotypes in Social Anxiety Disorder – a family study
The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…
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Fire and Human Origins
Correctly interpreting the patterns of fire evidence in the archaeological record will illuminate the origin of human fire use.
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Regulation of enzyme production in fungal cell factories
Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.
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Research themes
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.
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Invasive plant species, models for evolutionary change
Which traits did change due to the invasion process of plants and how do these traits contribute to the invasiveness of such species. What is the role of carbohydrate accumulation? What is the function of carbohydrate accumulation in plants? Is genetic variation depleted in invasive species under se…
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Education
The information below concerns courses that our group teaches in Leiden.
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Born to be shy?
An international mega-analysis on the neurobiological link between inhibited temperament and social anxiety disorder
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Versatile SNP genotyping
The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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About the programme
The Biology programme offers 4 research-oriented specialisations corresponding with the research themes within the three institutes involved. You can choose a more practical-oriented specialisation if you would like to combine Biology with education, management business, or science communication.
- Biodiversity
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Applied Neuroscience in Human Development (MSc)
Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.
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About the programme
Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.
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Functional analysis of genetic variants in PALB2 and CHEK2
PhD defence
- Prof Dr André Kessler
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Language and the human past
At LUCL, researchers aim to contribute to a comprehensive and informed perspective on the human past.
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Language and the human past
At LUCL, researchers aim to contribute to a comprehensive and informed perspective on the human past.
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Characterization of Cell-based medicinal products (CBMPs)
Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Neolithisation of Northeastern Africa
Studies in Early Near Eastern Production, Subsistence, and Environment, vol.16. Edited by Noriyuki Shirai.
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Abstracts
We warmly welcome late abstracts for Poster Communications! Late abstracts submission closes on the 1st of August 2022.
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Linguistic Contact in Italic Prehistory
The Latin language is a descendant of the widespread Indo-European family of languages. Recent ancient genetic studies have helped shed light on the likelihood that the Indo-European languages spread into a Europe that had already been populated by farmers for thousands of years.
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Programme structure
Through courses and research projects, you are trained by experts in the field.
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A global analysis of matches and mismatches between human genetic and linguistic histories
Lecture
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Re-inventing the Nineteenth-Century Tools of Unprescribed Modifications of Rhythm and Tempo in Performances of Brahms’s Symphonies and Concertos
PhD defence
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Redox catalysis for a sustainable energy infrastructure
The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…
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Rhythms of resilience: Individual differences in genetic and environmental effects on brain development
PhD defence
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Chromatin organisation & dynamics
The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…