This study proposes a theory for the encoding of specificity and definiteness in the Chinese nominal based on Cantonese, Mandarin and Wenzhou data.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Which adolescents are more at risk of developing social anxiety disorder later in life?

This dissertation and the corresponding films and recordings presented here are an effort to distil an approach to performing the orchestral music of Johannes Brahms that is significantly different from what has hitherto been produced in the fields of both Mainstream Orchestral Performance Practice…

Are there elements of the lost performance practice of the nineteenth century that we can rediscover and use to shed new light on the performance of Brahms’ music for orchestra today?

The main aim of this research is to understand the dynamics of identity within indigenous Caribbean communities as expressed through the practice of intentional cranial modification. A multidisciplinary approach will be applied to achieve this aim, combining current anthropological and sociological…

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

Tropical butterflies adapt to their environment to improve their chances of survival. The changes are triggered by hormone signals that transmit information about temperature to the butterflies' tissues. Biologist Ana Rita Mateus shows how a complex combination of environment, physiology and genetics…

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Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

A mere day after setting foot ashore in the Bahamas on October 13th 1492, Christopher Columbus notes the broad foreheads of the inhabitants of the Americas. These permanently altered cranial shapes are deliberately created through the application of pressure to the head of the infant in the first years…

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Lecture, This Time for Africa! Series

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

This dissertation investigates whether and how gradability is manifested in the nominal domain, as well as the implications this could have for theories of the representation of gradability.

This thesis investigates the syntax of object marking in Sambaa and the Bantu languages in general, with particular focus on Swahili and Haya, as points of comparison.

PhD defence

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Lecture

From basic science to real-world interventions

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

This research intents to redefine the limits of the electric guitar.

Examining the therapeutic potential of new semisynthetic lipopeptide antibiotics

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Studying the underlying principles of the nature of language.

Promotor: P. Stevenhagen, Co-promotores: B. de Smit, F. Andreatta

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?

Promotor: A. Kros

In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.

Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…