10,000 search results for “leiden” in the Public website
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Profinite groups with a rational probabilistic zeta function
Promotores: H.W. Lenstra, A. Lucchini
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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The assembly history of the milky way nuclear star cluster
Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven
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The acquisition of verbal morphology in cochlear-implanted and specific language impaired children
This dissertation aims at enhancing our knowledge of whether a CI provides sufficient access to auditory speech input to acquire verbal morphology by comparing outcomes of CI children to those of their normal hearing peers and to those of children with specific language impaired (SLI).
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Maintaining Order: Public Prosecutors in Post-Authoritarian Countries, the case of Indonesia
On 21 January 2021, Fachrizal Afandi defended his thesis 'Maintaining Order: Public Prosecutors in Post-Authoritarian Countries, the case of Indonesia'. The doctoral research was supervised by Prof. A.W. Bedner and Prof. J.H. Crijns.
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Biodiesel production using blue-green cyanobacterium Synechococcus elongatus PCC 7942
Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.
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Focal-plane wavefront sensors for direct exoplanet imaging: Theory, simulations and on-sky demonstrations
One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…
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Judgmental Adjustments in Revenue Management
On 12 November 2019, Larissa Koupriuchina defended her thesis 'Judgmental Adjustments in Revenue Management'. The doctoral research was supervised by Prof. J.I. Van der Rest.
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The International Labour Organisation: 100 years 1919-2019
The International Labour Organisation (ILO) was established in 1919 based on the premise that social justice is a condition for lasting peace. On February 2019 the ILO celebrated its 100th anniversary with an international symposium to consider the future of the ILO.
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Cooperation of International Organisations in Peacekeeping Operations and Issues of International Responsibility
Can international organisations be held responsible for violations of international law by peacekeepers in a peacekeeping operation?
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Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
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Topics in the arithmetic of del Pezzo and K3 surfaces
Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk
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Michel Orrit Lab - Single Molecule Optics
Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.
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Lights in a sea of darkness: constraining the nature and properties of dark matter using the stellar kinematics in the centres of ultra-faint
Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.
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Land rights and the forces of adat in democratizing Indonesia
On 9 January 2019, Willem van der Muur defended his thesis 'Land rights and the forces of adat in democratizing Indonesia'. The doctoral research was supervised by Prof. dr. A.W. Bedner and Prof. dr. J.M. Otto.
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Islam in North Africa: A Critical Return to Youth
In recent years, and especially since the ‘Arab Spring’ of 2011, a growing body of research, media reporting, and scholarly literature has focused on the role of ‘Arab youth’ as the drivers of social and political movements across the Middle East and North Africa.
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Ice and Gas in Protostellar Clouds and Planet-forming Disks
This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.
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Intermediate assessment in higher education
In higher education intermediate assessment is used in different ways. In her PhD research Indira Day shows that lecturers should be able to continue to have the freedom to use various test forms, because not one type of test is optimal.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU
On 3 September 2019, Ilektra Antonaki defended her thesis 'Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU'. The doctoral research was supervised by Prof. S.C.G. Van den Bogaert.
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…
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The Phonology of Shaoxing Chinese
This thesis presents a thorough survey of the central aspects of the phonology of Shaoxing Chinese from a synchronic perspective and on the basis of recent theoretical phonological developments, with the secondary goal of casting some light on current issues in Modern Chinese (Mandarin).
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Taxation of Cross-border Inheritances and Donations
On 3 June 2021, Vassilis Dafnomilis defended his thesis 'Taxation of Cross-border Inheritances and Donations'. The doctoral research was supervised by Prof. F. Sonneveldt and Prof. S. Douma (UvA).
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Historical and Comparative Linguistics
The study of language in change.
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Theoretical Physics
In the spirit of 'unity in diversity', our objective is to promote insight into and appreciation for the wonder that the same physical laws and mathematical concepts apply to the whole of nature, from the largest to the smallest energy and length scales. We strive for the application of abstract theoretical…
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A Grammar of Dime
This book presents the first comprehensive study of Dime, an endangered Omotic language spoken by about 5400 speakers in south-west Ethiopia. The study presents analysis of the phonology, morphology and syntax of the language as well as a sample of ten texts and an extensive word list.
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Solutions for CRitical Raw materials - a European Expert Network 2 (SCRREEN2)
How can Critical Raw Material policies/strategies be enhanced in the EU context?
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The comparative biology of language learning
A theoretical project on the insights gained by human (including infant), nonhuman animal and computational studies on artificial grammar learning; identifying the critical questions for future research by developing novel experimental and computational approaches to address these issues.
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Explorations of Water Oxidation Catalysis in Explicit Solvent
In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.
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The Diving Dutchman
Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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The syntax and licensing of Gapping and Fragmenting
This study investigates the syntax and distribution of the two elliptical phenomena Gapping and Fragments, as well as the movements involved in ellipsis contexts in general.
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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A grammar of Papuan Malay
This grammar presents an in-depth linguistic description of one Papuan Malay variety, based on fifteen hours of recordings of spontaneous narratives and conversations between Papuan Malay speakers.
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
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Sharia Incorporated
Sharia Incorporated: A Comparative Overview of the Legal Systems of Twelve Muslim Countries in Past and Present
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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People and Projects
Our team consists of the following members.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Library
The library of the Papyrological Institute is the most complete facility for papyrological studies in the Netherlands.
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The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism
On 21 March 2019, James Welch defended his thesis 'The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism'. The doctoral research was supervised by Prof. dr. P.B Cliteur.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.