The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

How is structural and functional brain development related to behavioral change in cognitive-control, impulse regulation, and socio-emotional functioning?

Nowadays children grow up with social media. This may influence the development of brain regions involved in social interaction. In their review article in Nature Communications, Crone and Konijn illustrate how neuroscience can contribute to a better understanding of how media and peers influence adolescents'…

This minor focuses on the cognitive processes that influence the interaction between the brain and the mind.

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

An Integrative Approach to the Hominin Record

Neuroimaging research has greatly advanced our insights on how the brain is organized. Now is the time for the next step: Imagine what would be possible when we cannot only map brain-functioning, but use neuroimaging to voluntarily regulate brain-activity!

This interdisciplinary minor emphasizes the diversity and complementarity of various cognitive neuroscience approaches to understanding the human brain.

Researchers have been working for centuries in mapping the human brain. But in the year 2017 some brain structures remain still not well mapped, especially those located at the brainstem. In this paper, we quantified the test–retest reliability of imaging the brainstem nucleus locus coeruleus in vivo…

Fundamental insights into the working of the adolescent brain help lecturers and parents to teach adolescents to function better. Professor Eveline Crone studies executive functions – such as planning and behaviour – in the adolescent brain.

The Brain and Education lab is a research group in the Institute of Education and Child Studies at Leiden University in the Netherlands. We use a Developmental Cognitive Neuroscience approach to study the development of complex cognitive processes involved in learning and academic skills such as reading…

Your brain responds in a predictable way when it encounters new or difficult tasks. This unique book teaches you concrete techniques rooted in cognitive science that will improve the way you learn and think about code.

Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.

The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.

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The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

This study is the first to directly relate brain development to sex differences and school performance. The results debunk the myth that brain development is slower in boys.

What is the neural basis of social decision-making across childhood, adolescence and adulthood and what are the developmental patterns in terms of behavior and brain activation?

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

This project looks at how the native language influences processing mechanisms of non-native language(s) as well has how it influences brain structure and functional connectivity.

Smartphone behaviors are so common but how does the brain generate this behavior? The Cognition in the digital environment laboratory (CODELAB) investigated the brain activity surrounding smartphone interactions with the help of Artificial Intelligence. According to their research, the brain fluidly…

Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

The Leiden Institute for Brain and Cognition (LIBC) is a network that stimulates interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition and focuses on science valorisation and outreach.

A neurobiological perspective on individual differences in social competence

Can playing certain games decrease cognitive decline or even enhance cognitive performance in the aging population?

Using brain imaging to discover the area in the brain that recognizes emotion.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

This project investigates properties of quantity expressions across languages from the perspective of how quantity is represented in the human brain.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

PhD defence

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

Serge Rombouts is a physicist whose PhD thesis was about functional MRI (fMRI). This visualises activity in regions of the brain. The appealing images of glowing brain regions that emerge from the computer are the result of calculations. According to Rombouts, this isn’t proper artificial intelligence.…

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

Children and adolescents really do use their ‘smart’ brain areas. This has been confirmed by an extensive and long-running study of the brain carried out by developmental psychologist Sabine Peters . Her findings can have important consequences for education. PhD defence 27 January.

There is a link in adolescents between brain connections and impulsiveness. Leiden researchers have discovered that these connections also predict which adolescents will make more impulsive choices two years further on.

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Our childhood years largely determine how we will fare later in life. In the first two decades of our life, our brain is still developing, which is clearly reflected in our behaviour. By studying how the young brain develops and how children behave, researchers can learn important information about…

A tried and tested medication for treating ADHD works differently than expected in the brains of healthy individuals during rest: rather than stimulating brain activity, it suppresses it.

Are disturbances to the brain, such as Alzheimer's or autism, linked to specific defects in the underlying communication networks in the brain? If this is the case, subtle changes in the networks can act as a marker for brain disturbances. Neuroscientist Serge Rombouts will be investigating this, together…

This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB

Novel language learning activates different neural processes than was previously thought. A Leiden research team has discovered parallel but separate contributions from the hippocampus and Broca's area, the learning centre in the left hemisphere. The right hemisphere of the brain also seems to play…

Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…