On this page you will find a list of trainings and tools offered for FGGA staff.

This section provides an overview of online tools for the study of the medieval Low Countries. The websites linked down below are often times both available in Dutch and English.

A functional study of chert artefacts from preceramic sites in Colombia (2002)

Enabling volume-restricted metabolomics using next-generation microscale analytical tools.

Overview of CML software and data

Software and Data of the department Industrial Ecology

Tools and Data of the department of Environmental Biology

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

TARA aims to accelerate research assessment reform through: Systematic review of new or innovative research assessment policies and practices at academic institutions, primarily in the United States and Europe Analysis & assessment of new or innovative research assessment policies and practices…

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

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Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotor: J.N. Kok, Co-promotor: W.A. Kosters

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Review of new technical decisionsupport systems in the environmental field, and application in water management decission processes.

Considering the absence of the human performer within a performance installation, the research centres around what is left of the human through traces such as sound or recorded voices, images, videos or movement and gestures. What do we perceive as ‚present‘, once the human is removed from the centre…

This paper critically compares seven widely used risk assessment tools for violent extremism, including the VERA-2R, the ERG 22+, the SQAT, the IR46, the RRAP, the Radar, and the VAF.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

How can we enhance inspiration in metric modal improvisation and subsequently, in modal composition?

CML report 192

On the 9th of April, Manolis Fragkiadakis successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Manolis on this achievement!

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

How many written parliamentary questions does each party put to each minister? Political scientists Simon Otjes (University of Groningen) and Tom Louwerse (Leiden University) studied the practice in Dutch parliament and found that parties use parliamentary questions strategically as part of their ‘permanent…

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Shining a light on the nefarious netherworlds of espionage, this is the first book to concentrate on the actual techniques and technologies used by early modern spies —from ciphers to counterfeiting, invisible inks to assassination

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?

The topic of this study is the portfolio that is being used in a teacher education institute as an instrument for stimulating reflection on their development as teachers by student teachers.

Promotor: A. Kros

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…

This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…

Develop a tool to assess land tenure, access to land and, and land tenure conflict in Timor-Leste

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…