178 search results for “antimicrobials stefan” in the Public website
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Stefan de Jong
Faculty Governance and Global Affairs
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Screening of animal venoms for antimicrobial compounds
Can animal venoms yield novel antimicrobial peptides?
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Stefan Hartman
Expertisecentrum SOZ
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Stefan Manegold
Science
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Stefan Rijnsburger
Universitair Facilitair Bedrijf
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Stefan Planjer
ICT Shared Service Centre
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Stefan Semrau
Science
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Stéfan Ellenbroek
LURIS
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Stefan Hoogland
Expertisecentrum Vastgoed
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Stefan Norbruis
Faculty of Humanities
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Stefan Romeijn
Science
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Stefan Pickl
Science
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Stefan Petrovic
Faculty of Humanities
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Stefan Wirken
Faculteit Rechtsgeleerdheid
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Stefan Sagel
Faculteit Rechtsgeleerdheid
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Stefan Pouwelse
ICLON
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Stefan Thewissen
Faculteit Rechtsgeleerdheid
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Stefan Cetkovic
Faculteit der Sociale Wetenschappen
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Stefan van Gils
ICT Shared Service Centre
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Stefan de Jong
Expertisecentrum SOZ
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Stefan Semrau Lab - Quantitative Single-Cell Biology
We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.
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Stefan van der Vorm
Science
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Clinical pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
PhD defence
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The role of animals in the epidemiology of antimicrobial resistance in humans
PhD defence
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Nathaniel Martin in podcast about antimicrobial resistance
Professor Biological chemistry Nathaniel Martin from the Institute of Biology Leiden is interviewed by the Netherlands Innovation Network on innovative scientific approaches. He talks about his work on designing new antibiotics and developing new molecules to make resistant bacteria susceptible again…
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Rubicon grant Stefan de Jong
His two year Rubicon project is about the effect of university policies on societal engagement of academics in the social sciences and humanities.
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Stefan Sagel on non-competition clauses
An open disagreement about a non-competition clause in the employment contract of a top business manager is a rare occurrence. Both the company and the employee are wary of the possible damage to their reputation that such a conflict could cause.
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Mariana Avalos Garcia
Science
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Nicola Thome
Science
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Dick Stufkens Prijs 2018 awarded to chemical physicist Stefan Vuckovic
The Dick Stufkens Prize 2018 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) will be awarded to Dr Stefan Vuckovic. In his thesis, Vuckovic presents a new and innovative approach to the quantum mechanical calculation of atomic and molecular energies. It lays the…
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
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Vidi Grant for Stefan Semrau: how does bioelectricity shape embryonic development?
Leiden biophysicist Stefan Semrau was granted an NWO Vidi earlier this month. He will use the grant to study the role of electricity in embryonic development and tissue regeneration.
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Improving antimicrobial prescription in primary care: a multi – dimensional approach to antimicrobial resistance
PhD defence
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Projects
An overview of Quantitative Pharmacology projects
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Key publications
Key publications of the Antiviral Pharmacology group.
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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The battle against antimicrobial resistant bacterial infections - next stage development of antimicrobial peptides
PhD defence
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Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…
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Chemistry & Chemical Biology approaches toward novel cyclic peptide antibiotics
Can cyclic peptides provide a new generation of antibiotics?